What are protein interactions?
Protein interactions describe how biological processes occur within cells (1). These interactions provide an important summary of known connections among clusters of proteins (2). Databases, such as STRING, can provide some information of known interaction networks, and can be useful in designing new experiments.
Results
Using STRING, I generated a primary relationship diagram of ALDH2 and its interactions with other proteins for humans and mice. Most of these proteins function somewhere in the general metabolic process. All of the proteins in the human network function in the oxidation-reduction process. There were no proteins that are directly associated with controlling the cell cycle. Therefore, no proteins in this network are knowingly affecting cell proliferation directly.
References:
1)De Las Rivas, J., & Fontanillo, C. (2010). Protein-protein interactions essentials: key concepts to building and analyzing interactome networks. PLoS computational biology, 6(6), e1000807. https://doi.org/10.1371/journal.pcbi.1000807
2)Kuzmanov, U., Emili, A. Protein-protein interaction networks: probing disease mechanisms using model systems. Genome Med 5, 37 (2013). https://doi.org/10.1186/gm441
Images:
Header:https://www.genengnews.com/insights/protein-protein-interactions-get-a-new-groove-on/
1)De Las Rivas, J., & Fontanillo, C. (2010). Protein-protein interactions essentials: key concepts to building and analyzing interactome networks. PLoS computational biology, 6(6), e1000807. https://doi.org/10.1371/journal.pcbi.1000807
2)Kuzmanov, U., Emili, A. Protein-protein interaction networks: probing disease mechanisms using model systems. Genome Med 5, 37 (2013). https://doi.org/10.1186/gm441
Images:
Header:https://www.genengnews.com/insights/protein-protein-interactions-get-a-new-groove-on/