What are protein domains?
Proteins are composed of basic functional units called domains. Most domains have a specific function within a cell (1). These domains can be determined quickly using PFAM or SMART.
ALDH2 domains
Discussion
PFAM and SMART both identified the Aldedh protein that is typically found within aldehyde dehydrogenases. This domain is essential for ALDH2 to function in reducing acetaldehyde. Since ALDH2 is an enzyme, its domains do not differ significantly between species.
References:
1)https://www.ebi.ac.uk/training/online/course/introduction-protein-classification-ebi/protein-classification/what-are-protein-domains
2)http://smart.embl.de/smart/do_annotation.pl?DOMAIN=Pfam:Aldedh&START=537&END=774&E_VALUE=4.7e-31&TYPE=PFAM&BLAST=QSPGTQSSRPIQDSSGKVSSYVAEGGAKDIRGAVEAAHQAAPGWGAQSPRARAGLLWALAAALERRKPVLTSQLERHGAAPTVAKIEVELSVRRLQTWGTRVQDQGQTLQVTGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAHGNAVVLVPSGACPLLALEVCQDIAPLFPAGLVSVVTGDRDHLTRCLALHQDVQALWYFGSAQGSQFVEWASAGNLKSVWVNRGFPRA
Pictures:
Header:https://www.wikiwand.com/en/ALDH2
1)https://www.ebi.ac.uk/training/online/course/introduction-protein-classification-ebi/protein-classification/what-are-protein-domains
2)http://smart.embl.de/smart/do_annotation.pl?DOMAIN=Pfam:Aldedh&START=537&END=774&E_VALUE=4.7e-31&TYPE=PFAM&BLAST=QSPGTQSSRPIQDSSGKVSSYVAEGGAKDIRGAVEAAHQAAPGWGAQSPRARAGLLWALAAALERRKPVLTSQLERHGAAPTVAKIEVELSVRRLQTWGTRVQDQGQTLQVTGLRGPVLRLREPLGVLAVVCPDEWPLLAFVSLLAPALAHGNAVVLVPSGACPLLALEVCQDIAPLFPAGLVSVVTGDRDHLTRCLALHQDVQALWYFGSAQGSQFVEWASAGNLKSVWVNRGFPRA
Pictures:
Header:https://www.wikiwand.com/en/ALDH2